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              傅磊課題組階段性地完成瞭“通過化學手段幹預線粒體活性”的研究,在PNAS雜志上刊出文章 “Moderation of mitochondrial respiration mitigates metabolic syndrome of aging” 。

              Mito-Fu 或能延長人類健康壽命的藥物

              Mito-Fu, Probable Drugs for Human Health Span

              人類健康壽命(Health Span)是指他健康的時間長度,而不僅僅是活著的時間。根據美國國傢科學院院刊(PNAS)2020年4月17日的一篇文章[1],上海交通大學和斯坦福大學的科學傢們設計瞭一類新化合物,2-(2-(4-甲基噻唑-5-基)乙氧基)-2-氧乙基三唑的三苯基膦衍生物(簡稱TPP-噻唑,是Mito-Fu傢族的成員)。在小鼠體內,這類化合物能精準地靶向線粒體,緩解衰老相關的疾病,阻止年齡相關性肥胖和血糖並發癥的發生,並延長小鼠健康壽命。

              A person’s health span is the length of time that the person is healthy – not just alive. According to a paper in the April 2020 issue of Proceedings of the National Academy of Sciences of the United States of America (PNAS)[1], scientists from Shanghai Jiao Tong University (SJTU) and Stanford University designed a novel drug, a triphenyl-phosphonium derivative of the 2-(2-(4-methylthizol-5-yl) ethoxy)-2-oxoethyl triazole (TPP-thiazole), a member of Mito-Fu family. This compound specifically targets mitochondria and consequentially alleviates aging diseases, impedes the onset of age-associated obesity, blood glucose complications, and improves health span in mice.


              “We have discovered a proprietary mechanism to improve mitochondrial quality and quantity in the animal model.” says Professor Fu at SJTU School of Pharmacy, a corresponding author of this PNAS paper, “these compelling results in mice show that the impact of this compound deserves a closer look as there are many potential clinical applications based on this proprietary mechanism.”


              “This study reports a new, seemingly innocuous drug that inhibits respiration in mice, strongly diminishing the adverse effects of aging and creating new mitochondria, the power cells of all air-breathing animals. This water-soluble compound treats type II diabetes and reduces inflammation.” Professor Collman at Stanford emphasizes.

              線粒體存在於真核細胞,它將營養物質轉化為能量,但線粒體的功能會隨年齡增加而衰退。該研究論文的第一作者,傅磊課題組的博士研究生M. Tavallaie解釋道:“線粒體就像體內的發電機,提供細胞運行所需的能量,但同時也會產生有害的‘副產物’。這些副產物會加速衰老,引起年齡相關性疾病。因此,我們通過幹預細胞器,誘導有規律的停頓,使它們恢復活力。”

              Mitochondria are the part of eukaryotic cells that convert nutrients to create energy. Mitochondria decay with age. “Mitochondria are like a furnace in the body; they produce energy but at the same time make harmful byproducts which accelerate aging and expedite the age-linked diseases. Therefore, we believe that this intervention by inducing a regulated pause to these organelles allows them to rejuvenate,” according to the study's lead author, M. Tavallaie, a Ph.D. candidate in Dr. Fu’s lab at SJTU School of Pharmacy.


              This research stemmed from the synthesis of a biomimetic compound that imitates the respiratory enzyme, cytochrome c oxidase (CcO) in the mitochondria. Based on this enzymatic mimic a series of novel compounds were discovered by the Collman group at Stanford [2-6].


              In this PNAS paper, the SJTU research team randomly divided 60 male mice into compound-treated and control groups and characterized a variety of mitochondrial functions, such as respiratory activity, mitochondrial bioenergetics, and biogenesis, and few age-associated comorbidities including reactive oxygen species (ROS) production, glucose abnormalities and obesity in mice over a period of 18-month treatment. The team was able to demonstrate that chronic moderate inhibition of CcO reduces ATP synthesis, promotes mitochondrial biogenesis and mitophagy, subsequently decreasing ROS production and mitochondrial decay, and rectifying vital cellular energy metabolism regulators; thus, effectively refining energy homeostasis and curbing obesity and glucose irregularities linked to aging.


              “We have demonstrated that a member of Mito-Fu family boosts metabolism and mitigates aging complications. New derivatives are being examined for efficacy. Future research will test these drugs on larger animals with an ultimate application in humans.” Dr. Fu added, “at this point, we have uncovered a myriad of active compounds. These are small molecules with low levels of toxicity. We have also discovered a simple strategy to increase the activity of this new class of drugs. Understanding the underlying mechanism may allow us to develop even more active chemicals directed specifically in particular disease states and to translate the intervention in humans.”


              [1] M. Tavallaie, R. Voshtani, X. Deng, Y. Qiao, F. Jiang, J. P. Collman, L. Fu, “Moderation of Mitochondrial Respiration Mitigates Metabolic Syndrome of Aging” Proc. Natl. Acad. Sci., April 2020. https://doi.org/10.1073/pnas.1917948117(點擊閱讀原文)

              [2] J. P. Collman, L. Fu, P. C. Herrmann and X. Zhang, “A Functional Model Related to Cytochrome c Oxidase and Its Electrocatalytic Four-Electron Reduction of Dioxygen” Science, 275(1997)949.

              [3] J. P. Collman, L. Fu, P. C. Herrmann, Z. Wang, M. Rapta, M. Broring, R. Schwenninger and B. Boitrel, “A Functional Model of Cytochrome c Oxidase — Thermodynamic Implication” Angew. Chem. Eng. Edition, 37(1998)3397.

              [4] J. P. Collman and L. Fu, “Synthetic Models for Hemoglobin and Myoglobin” Acc. Chem. Res., 32(1999)455.

              [5] J. P. Collman, R. Boulatov, C. Soundland and L. Fu, “Functional Analogs of Cytochrome c Oxidase, Hemoglobin and Myoglobin” Chem. Rev., 104(2004)561-588.

              [6] C. Barile, P. C. Herrmann, D. A. Tyvoll, J. P. Collman, R. A. Decreau and B. S. Bull, “Inhibiting platelet-stimulated blood coagulation by inhibition of mitochondrial respiration” Proc. Natl. Acad. Sci., 109(2012)2539.